Antidepressents often cause a variety of side-effects, which settle down within a few weeks, as the system adapts to their intake. Some people take medication with no side effects what so ever, and others experience varying conditions - the variance is caused by the drug, and the individual taking it. Some people have taken seroxat with no discernable effects at all, including relief from depression, and a GP will normallly prescribe an alternative in these cases. Some people experience nausea, loss of appetite, insomnia, and loss of libido, but these can be caused by any drug of this type - it's a case of trial and error for people to find the anti-depressent that suits them.