Yep...let's take a seedless orange for example, a strong rootstock of, again for example, a Navel orange is grown from seed. When the seedling is big enough, it is cut back to a certain height and the seedless variety is then grafted onto the seedling.
As a result, you get a strong growing root and stem with the variety of orange you want to grow.
Just about all fruit is grown this way especially apples....as well as roses and other ornamentals.