You'll also find that regional jets and the smaller planes from the "big boys" (737, A319) are designed for more "cycles". A cycle is one cabin pressurisation or in other words, one take off and one landing.
This pressurisation stresses the fuselage and in time will increase the likelihood of fatigue failures. A B777 flying from London to Singapore will possibly go through 2 cycles per day where a BAe 146 flying from Manchester to Dublin may go through 10 or 20 (complete guess!). Unless the structure is engineered for these higher cycles, it's effective working life would be reduced significantly.
You can get high-cycle big planes like the B747's they use in Japan since they're moving so many people internally, they need big planes. These are heavier though. A long haul operator won't want the extra weight because it costs money to fly this extra metal (or composite) around for the life of the plane.