For laugh out loud value I have to say Scrubs is one of the better ones, but I watched M*A*S*H the first time around religiously and it was always hilarious but sometimes so poignant.
As an over-the-pond dweller, I've no favorite, but a number make the short list: Scrubs, Sports Night, Just Shoot Me, Murphy Brown and The Bob Newhart Show. To me, Cheers and Frasier were best in the earlier seasons.
Frasier, Scrubs and My Name Is Earl for me. I did like the early series of Will And Grace, but then it got stupid, wheeling out a different "surprise" guest star nearly every week. Ho hum..
I notice no-one's mentioned 'Friends'
(You can't do 'sarcasm' in type so this explanation will have to do.)
what a rotten show that was. why did it run so long?
anyway, my vote is for 'Frasier'. Some people rave for 'Curb Your Enthusiasm' but I've never seen it.
Frasier
Bilko
Seinfeld
Friends
Mash
Taxi
Jack and Karen
Grace under Fire
Roseanne
The Dick Van Dyke Show
Cheers
The Cosby Show
Fresh Prince
My Three Sons
Petticoat Junction.