Anything Mr Osborne does is far more directed towards ensuring he secures the keys to the house next door than it is to do with the economic wellbeing of the UK.
However, to the specifics, I see these two things as largely unconnected. His prime concern should be to bring down the deficit and debt. He can secure 22bn of savings at a stroke by cutting overseas aid (sorry, “development”) to nil (£11bn) and campaigning for a Brexit thus cutting our contributions to the EU to nil (currently somewhere between £12bn and £20bn, depending who you believe). This amounts to about a quarter of the annual deficit and the savings could be secured at a stroke with no effect on UK citizens at all.
Cutting a few bob off the benefits for vulnerable people will not secure anything like those savings. Having said that, there are large numbers of people on receiving disability benefits who are not too ill to work. You can see them every day. His efforts would be better spent in identifying them.