Talbot, the personal interactions between de Gaulle and MacMillan were very close, at the end, to begging:
//Mr Macmillan, a weary-looking father figure, at last held out his hand yesterday and offered to try to lead the Commons and the country into Europe, if he can find the way...
Mr Macmillan made it clear that now, after his long contemplation, he wants to go in. He also made it clear why. It might have been a European political community he was talking about. He spoke of the struggle for freedom, and said it was both our duty and our interest to add to Europe’s strength in that struggle.
He spoke sombrely, to Labour and Tory questioners alike, of what might happen if we find that we cannot go in after all. As for his own idea of the chances of success, he told Mr Grimond that he was “not confident, but hopeful.” //
(Guardian, 1961)
It took two years of trying before de Gaulle finally said "Non". Fill in the gaps yourself, if you're interested, but it's odd to have this fixation on Edward Heath when he was merely following the path laid down for him by MacMillan.