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Need reassurance, please - DM Prize Crossword

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Jock13 | 07:57 Sat 14th May 2011 | Crosswords
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18down,7 letters, This neutral dose is sure, if mixed, to make a cure possible.
Is it PLACEBO and if so, where's the word play, please?
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I was stumped like you - until now.
'a cure possible' minus 'is sure' gives the anagram of placebo.
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Many thanks, Dinkypuzzled - I hadn't spotted that - feel better now.

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