Although I can't parse the clue properly, two things come to mind.
A roach is used in a hand-rolled (marijuana) cigarette, as opposed to a 'ready-made' one; it is also a street name for Rohypnol, a depressant which would get you 'down'...
The clue that shows the possible R is the R is STORM.
A middling position to be in when there's a cyclone around (5-6)
?????-C?N?R? which we deem to be STORM-CENTRE
The A comes from
The ring is concealed by Karen Andrews = ARENA
The T in STORM comes from another difficult clue.
Provided with a drink when given medical attention (7) ??E?T?D
which we deem to be TREATED although we don't see where the drink is, other than treating someone (to a drink).
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