Brain seized up - stuck on the followingand any help would be much appreciated viz 8d Blown up and shot in pursuit of drug (4) P?I?; 10d Black, far from bold, shot of commander at the front (5) E???N; 49ac tips for new area manager out for growth (4) ?I?T and 15ac one could use PR venture to vilify, partly spinning (5) ??T?R - have been at these for hours!