1a) Take a big risk in e.g. Shaw's 'Saint Joan'? (4,4,4)
1d) Worrying sign left on medical department (7)
3d) Rodent's new treat across river was limited at first (5,3)
7d) Milliner's in special top designed to avoid injury (12)
10d) Dodgy dealer gasped and got ready to be frisked (6-6)
Apology for having no lettrs. All help much appreciated