Many thanks to all who replied. These solutions just weren`t on my wavelength! I`m still left with one which doesn`t quite chime - 22 down U? E?D -greatly affect winning margin - Answer is presumably UP END but I can`t see why.
Sorry, boxtops and scorpiojo - I did somehow manage to miss out the clues for two of my questions - doh! Thanks, dannyk13 - I do not think of "end" as meaning "margin" - back to the OED.