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Toughie

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E3EJH | 09:24 Fri 19th Feb 2016 | Crosswords
2 Answers
Not going well this morning
1d. Set up plan to guard pine arboretums first tree (8)
2d. Nothing new in arch needing a brush up (8)
10a. Dire note in brass instrument to meet our needs (10)
17d. Subject of medical research yet to have host almost replacing heart (4,4)
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1d.Magnolia
2d.Slovenly
10a.Horrendous
17d.Stem cell
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