The Week 1065

[ALCHEMI]

Can you help me with two, please:
27a look up this in composition, loud rather than quiet (6) s???t?
5d lady bound in original sin (4) ???a
Thank you

[Sam1960]

5. gina (hidden in the clue)

[Questioneer]

shufti anag of up this f replacing p

[sarumite]

I've just seen this and the answer is ISLA not GINA!
Unfortunately, the clue has been incorrectly shown, it should read:
5D Lady bound UP in original sin (4)