10a: An actor playing Hamlet, Macbeth, Othello etc (9): ??a???????
5d: A cure for all ills(7): ????c??
16a:Opulent alcohol abuser(4): ?u??
9d: To separate grain from husks and straw(6): ?h?e??
12a: Affinity, connection(7): ??n????
4d: LSD user down for the day? (7): ???????