As you can see, I'm not doing well- any help most appreciated! 1D) Straight up & down: ?E???, 4D) Drop nasty Ecstasy inside: ?E??, 17D) Brown perhaps, in charge of country: ??S???, 18D) Regular general accepting award: ??S?L?E?, 23D) Flipping crude journalist produces flask: ?T?A?, 25D) Carnival city with time for extravaganza: ??O?