You have to do the numbers
Gravity is a pretty weak force and I'm not sure that over the gargantuan distances that we're talking about it amounts to a whole hill of beans
The mass of our galaxy is about 10^42Kg small estimate for the size of the universe about 10^50 G 6.67300 × 10-11
So the force between two galaxies at that range is about 10^-25 N
That is so minute that any random variations in matter distribution will have a much greater effect
Trust me - the calculations going into the models trying to explain the Universe are pretty sophisticated and the chances of people slapping their foreheads and saying "Silly us the Universe is Newtonian after all we just forgot to account fot this" is remote
http://en.wikipedia.org/wiki/Lambda-CDM_model
Is the best model so far