Cefaclor antibiotic

[prashant]

What is the history and development of the drug cefaclor?

[moppettshow]

Hello,

This isn't a specific answer, but might help:

The cephalosporins are broad-spectrum antibiotics which are used for the treatment of septicaemia, pneumonia, meningitis, biliary-tract infections, peritonitis, and urinary-tract infections. The pharmacology of the cephalosporins is similar to that of the penicillins, excretion being principally renal. Cephalosporins penetrate the cerebrospinal fluid poorly unless the meninges are inflamed; cefotaxime is a suitable cephalosporin for infections of the CNS (e.g meningitis).

The principal side-effect of the cephalosporins is hypersensitivity and about 10% of penicillin-sensitive patients will also be allergic to the cephalosporins.

One brand is called 'Keftid'; I don't know which compnay manufactures it, but I'm sure a quick internet search would give you an answer; and perhaps the site would give you its history.