http://www.aerospaceweb.org/question/atmospher e/q0291.shtml
Vacuums are indeed lethal: Under extremely low pressure air trapped in the lungs expands, tearing the tender gas-exchange tissues. This is especially grave if you are holding your breath or inhaling deeply when the pressure drops. Water in the soft tissues of your body vaporizes, causing gross swelling, though the tight seal of your skin would prevent you from actually bursting apart. Your eyes, likewise, would refrain from exploding, but continued escape of gas and water vapor leads to rapid cooling of the mouth and airways.
Water and dissolved gas in the blood forms bubbles in the major veins, which travel throughout the circulatory system and block blood flow. After about one minute circulation effectively stops. The lack of oxygen to the brain renders you unconscious in less than 15 seconds
ne 1965 study by researchers at the Brooks Air Force Base in Texas showed that dogs exposed to near vacuum�one three-hundred-eightieth of atmospheric pressure at sea level�for up to 90 seconds always survived. During their exposure, they were unconscious and paralyzed. Gas expelled from their bowels and stomachs caused simultaneous defecation, projectile vomiting and urination. They suffered massive seizures. Their tongues were often coated in ice and the dogs swelled to resemble "an inflated goatskin bag," the authors wrote. But after slight re pressurization the dogs shrank back down, began to breathe, and after 10 to 15 minutes at sea level pressure, they managed to walk, though it took a few more minutes for their apparent blindness to wear off.