Amyloidosis

[SKA]

What is the difference in Familial renal amyloidosis and Glomerular amyloidosis?
and does it affect both animals and humans?

[Clanad]

Amyloidosis is a disorder of protein folding in which normally soluble proteins undergo a conformational change and are deposited in the extracellular space in an abnormal fibrillar form. Accumulation of these fibrils causes progressive disruption of the structure and function of tissues and organs, and the systemic (generalized) forms of amyloidosis are frequently fatal.(Source: Compendium on Continuing Education for the Practicing Veterinarian ) The deposition of the affected protein can occur in many places in the body. Renal amyloidosis affects the kidneys. The Glomeruli are specific structures within the kidney and can be the loci for the protein deposition.

The Familial denotation refers to suspected but unproven inheritance of the tendency towards amyloidosis. Seen in certain breeds of animals more than others, such as the Abyssinian breed of cats and the Shar Pei breed of dogs, raising the suspicion of inheritance.

Seen in humans and can be transmitted by contact with the infected urine of animals or mosquitos... known locally as Mediterranean Fever (Source: Veterinary Clinics of North America: Exotic Animal Practice )