I doubt anyone has, or ever will, come up with a theory to explain the origin of the Universe that can be meaningfully tested. Still, it's not too hard to see, even in our limited (present) understanding, hints of how a universe could spontaneously form. OG has already mentioned the Uncertainty Principle -- although I'm not sure his interpretation afterwards is the clearest -- and, on its own, that can provide the hint I mean.
I'm too tired to go too far into it, but the point is essentially that "nothing" is too exact a state, so that there may be no such thing as a perfect vacuum. By extension, there's probably no such thing as a perfect state of utter oblivion in which nothing exists at all, and there is not even a space and time to define the existence of nothing.