The significance of "Iscariot" is uncertain. There are two major theories on etymology:
* The most likely explanation derives Iscariot from Hebrew איש־קריות, Κ-Qrîyôth, or "man of Kerioth". The Gospel of John refers to Judas as "son of Simon Iscariot",[2] implying it was not Judas, but his father, who came from there.[3] Some speculate that Kerioth refers to a region in Judea, but it is also the name of two known Judean towns.[4]
* A second theory is that "Iscariot" identifies Judas as a member of the sicarii.[5] These were a cadre of assassins among Jewish rebels intent on driving the Romans out of Judea. However, some historians maintain the sicarii arose in the 40s or 50s of the 1st century, in which case Judas could not have been a member.[6]
http://en.wikipedia.org/wiki/Judas_Iscariot