try pressing F8 during start up and selecting normal mode from the selection that comes up.
Though are you sure you are in safe mode, does it actually say "safe mode" in the 4 corners of the screen?
You might just be viewing a standard VGA screen, in which case right click on your desktop background and select properties and then click the settings tab and see if you can move the screen resolution slider up to a higher setting.
if you can't and it doesn't say safe mode on the screen you may have to reinstall your graphics drivers.