I used opera for a long time a while back but these days use Chrome. To be honest I don't notice much of a difference. I expect the same is true of most browsers, at least for most users -- the differences are often fairly subtle and if you basically use the internet for news/ email/ AB then one browser is just as good as the other.
One issue with Opera is that it's fairly niche and, if I remember correctly, sometimes reads information in a different way that websites aren't designed to cope with. On occasion that means that some websites don't display properly in Opera (or something along those lines). It's a relatively minor issue though.