It should be very straightforward. The only problem I've ever heard of when people have done it is that, depending upon your email account settings, you
might find that you get lots of old emails re-delivered to your iPad. However, importantly, you shouldn't actually lose anything though.
To delete:
https://www.pickaweb.co.uk/kb/delete-email-account-ipad/
To create again:
https://mediatemple.net/community/products/dv/204644940/how-can-i-set-up-email-on-an-ipad
(That link assumes that you'll be using an 'other' account, rather than one from the list offered on your iPad. Just choose whatever's appropriate).