most people use these programs in conjunction with each other. Not many programs get rid of or protect you from everything, so using more than one helps. I have Avast Antivirus and Ghostwall firewall for security and virus protection. Crap Cleaner, Ad-Aware SE, Spybot, Stinger and regcleaner to get rid of all the other crap. I run those and then if everything is running perfectly, I turn off system restore and then turn it back on again and set a new clean restore point.