Depends what you like doing - plenty of museums, theatres etc. There's the castle & cathedral, a trip down the River Vltava, excursions to nearby places of interest. The trams are an excellent and cheap way of seeing round the (quite small) city and getting from place to place - the no 22 goes near pretty well all the major sights.
Give me a bit of an idea what kind of thing you're looking for and I'll tell you if it's a) available and b) any good! As I've said several times in response to questions about Prague (sorry to bore other ABers with the same stuff again!) I lived & worked there for a time and know it pretty well. I'll be there myself in November - it'll be cold, probably a bit damp & foggy - about the same as here, in fact.