In fairness nothing is 100% safe, and there have only been 2 serious nuclear incidents. The Russian one due to a poorly designed test which turned off vital protection, and the Japanese one that was due to poor siting and a tsunami. Neither are going to be applicable here as long as one employs test creators who know what they are about.
As for the waste issue, for sure it needs careful handling but it's not got a half life of infinity, and in any case there's no reason to suppose science won't find a way to make it inert at some point in the future; just so long as it isn't stored where we can't get to it again, and maintained so containers don't deteriorate. And until there is a viable alternative it seems to be the only option for present and near/mid future energy needs.