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Thanks to all. I had thought of "TAKE 2" initially, but abandoned it because the 2 would become the third letter of the answer to "One running business from home?" (7), which now (thanks to "ARIENZO") looks like N?2?K?R. The digit 2, however is definitely correct because it forms part of the concealed message contained in the completed grid :- GOOD RIDDANCE 2020.
The first 2 comes from 2 AND SIX for "Old pieces of eight" (not 1 AND SIX as suggested) and is not a problem as the 2 is unchecked. But I cannot see how to solve N?2?K?R. Any ideas please.