A couple of questions:
The CD drive is often the "D" drive (though not all the time). What is your "D" drive?
Can you play music or games or load in programs using your "E" drive?
What speed/RAM is your machine and what version of Windows are you running?
Has the drive EVER burnt CDs?
I'd try downloading another burning program (some free ones at
http://www.snapfiles.com/Freeware/gmm/fwcdburn .html - I'm afraid that I haven't used any of them) and seeing if those will work. If not, then I would personally pop open the case and loom for loose connections before totally giving up on the drive.