I think you can if you want too. I guess it's the place for everything and everything in its place thing.
I'm funny about my work desk, always has to be neat and tidy before I go home. Used to work with some very untidy lads and used to find myself serrupticiously tidying up their desks while in the vicinity :) I just make sure I have somewhere easy to put things such as penpots, filing trays, paperclips, rubberbands and such so they automatically go where they should.
If things are getting a bit untidy in the day I take 5 to just have a quick tidy up before starting again.
Do you have loads of clutter? If so a big ruthless clearout can help and you can give stuff you don't need anymore such as clothes to charity.
Try and be surface tidy at first, get a load of space saving things such as pretty boxes and chests and rather than just pile different crap in allocate one for specific things, just be ruthless and shove them in and any crap in a binbag until everything's out of sight eg wardrobe, under the bed, drawers, so it "looks" tidy then once you can keep it like that go through and tidy the boxes one by one in your own time.