yes I have tried the "fillers" restyline its called ,I worked for a private doctor up untill recently.Most of the work was involving botox (used above the nose) collogen and restyline used below the nose. I hade my upper lip and the lines that come down from your nose (can't remember what they call em ) any way i found it quite painless It just stung a bit,The results were excelent , but really only last s 6 to 8 months .I had it done for 1/2 price at � 145 . but i couldnt possibly afford to have it done at �290 every 8 months,but inside myself it made me feel really refreshed like iI had had a real boast,