This actually means that you'd need to create a self sustaining colony on the first attempt.
In some ways that makes it harder.
If it's for scientific research this means that it becomes harder to return samples to Earth for proper analysis.
You still have to answer the question "Why are we spending gigantic amounts of money to do this in the first place"
Is there a real need or is it just to fullfill the unfullfilled Star Trek fantasies of the Apollo Generation?
So here's a budget
Do you want to spend it putting some Robinson Crusoe figure on Mars?
Or do you want to put it into the fusion program to create clean sustainable energy?
Or maybe cut taxes?