just checked out Dune, but that started in the 1960s. My guess is Sexus was a lot more controversial than Asimov's work - but it was by Henry Miller. Henry James did not do that sort of thing at all.
'Gormenghast' was published in 1950. It is written by Mervyn Peake (who was going round the bend when he did the last bit) and is brilliant, though very surreal. If you can get into it, I highly recommend it. The 3 books are 'Titus Groan', 'Gormenghast' & 'Titus Alone'.
Jno, I thought the Sexus/Plexus/Nexus trilogy was in the 40s too before I checked, but my copy of Sexus definitely has Copyright 1962 in the publishing blurb.
maxi, I got the dates from a website on Miller - I suspect it was privately published, probably at something like the Olympia Press (who used to do a lot of racy stuff you couldn't publish in English-speaking countries), and he then went on to find a US publisher in a more liberal era. But between your dates and mine, I'm still not sure this is what tiny tim is looking for, though it sounds as if it ought to be.