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For more on marking an answer as the "Best Answer", please visit our FAQ.this equation first appeared as part of what was basically the appendix to the special theory of relativity.
This deals with the the way things like time and space behave when you get close to the speed of light.
The later General Theory of Relativity was to do with how these things were affected by extreme gravity.
In some nuclear reactions more matter goes in than comes out. Some matter appears to be distroyed. It is actually converted to energy. This energy is the e the lost mass is the m and the c is the speed of light. c squared is roughly 100,000,000,000,000,000.
So you see you only have to distroy a tiny amount of matter to create a gigantic amount of energy.
It is the basis of both nuclear weapons and the sun