well first off im not even gonna ask why youve bothered with vista coz theres so many problems out there with it xp was the bees knees while vista looks nice theres really not a lot of software out there that runs well on it perhaps when the next service pack comes out, you could try running the programe in xp windows compatibility mode or earlier (thats done by right clicking the icon) and running as administrator failing that look on a leading torrent site theres a few vista compatible registry cleaners out there i think vista manager is a good one covers just about everything hope my waffling on has helped in some way