When Grape and tumor (US spelling) are googled together, it gives:
The tumor is often recognized as it prolapses from the introitus with a characteristic gross appearance of grape-like clusters of tumor masses.
rumours topped is umours with T gives tumours (so grapes possibly).
Now all the clues that tumours crosses with are solved except for one.
32. Letter bishop's penned goes astray (4)
would be ERRS (R from tumours is second letter in ERRS).
But how to fit "letter bishop's penned" with the answer?