It depends on several things.
If there is a roomstat in the room, then it will operate the circulation pump until the set temperature is reached. With a large rad, obviously that will happen sooner than with a small rad. The boiler will then sense cold water returning. That should fire up the boiler, but, only if the boiler temp stat is not set too high.
If the rad has a TRV (thermostatic rad valve) then ......... this will shut off sooner with a large rad for obvious reasons. If the rad is too small, it may never shut off.
So.... several things need to be co-ordinated for efficiency.........
TRV setting
Size of rad
Roomstat setting
Location of roomstat
Boiler size
Boiler temperature setting
Rad balancing
Insulation and heat loss factors
I think that's enough to be going on with ;o)
It's not terribly complicated. Everything just needs to be co-ordinated that's all. Otherwise, you may get lucky, but it would be trial and error.