1d) Medicine formulated without iodine found locally. (7)
5a) European is not entirely relevant (6)
12a) Bottom of building dominates supply of shade. (11)
16d) Friend crosses border first (6)
Apology for having no letters. All help greatly appreciated.
thank you mac44, mallyh and lyhalf any suggestion for 16d) Flyhalf are you sure about foundations, I have REBUS for 6d, which makes the 7th letter of 12a) S not T - please advise