We support the Cerebral Palsy Alliance on a regular basis.
At Christmas time we spend quite a bit of money with Tear Australia. They support many different needs, mainly in third world countries.
You purchase a "gift", they send you a card, you personalise the card and send it on to someone instead of buying them a Christmas present, (what do you buy for some people?)
Last year my mum received a goat, my dad got an education and my younger brother received a toilet, and the list goes on.
The money spent then goes to a project along the lines of what you have purchased.
http://www.usefulgifts.org/site/view-all