Four not sure of: 15a set off in vessel heading east after opening scene (8) (Aspirate?) 21a endless difficulty framing suitable answer that's useful (21) (p?a?i?a?l?). 22a Asian leader in past hiding yen in part of Ireland (4) (Mayo) and 19d. Fish European river for sport (7) (snooker?) All help greatly appreciated. Many thanks.
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