Impossible to say without trying it. Having said that you have to be aware of the dimensions of any vehicle you are driving but a very large vehicle could be daunting.
Having driven high vehicles I've always been very aware and checked the height of every height limit I've come across.
I think getting used to the length is probably most difficult ie, having to swing out on corners and it's "behind you" - you are warned about height, you can see width but length is out of sight.
I suspect the power-to-weight ratio might be a problem until you get used to it so, together with length, pulling onto a roundabout will need a bit more thinking about.
Avoiding other vehicles that don't realise that you "cut" corners another hazard.
Reckon I could. I own a bus service (no double deckers though).
It's a matter of driving accordingly. The bigger the load the slower and more cautious the driving.
One must be aware of the size of the vehicle.
A mate of mine who was a bus driver told me that there was absolutely no difference in driving a double decker from a single decker as they were both the same length and width. The only thing to watch out for was low bridges.
Not just low bridges, but also street furniture. Its surprising how much a high vehicle tilts if there is a camber on the road, sufficient that it could hit road signs, traffic lights, trees etc.
The other new thing to learn would be rear overhang swing - something car drivers don't have to worry about.
Beg to differ here Ratter. A heap different than a car, front and rear overhang, sweep, weight, stopping distance, acceleration ability.
Not difficult to drive safely but nothing like a car.
Just a matter of being aware of the vehicle and the load.