I think leaving the EU makes good sense for the English economy. We vastly import more from the EU, in cars alone (Mercs, VWs Volvos, Citroens, Fiats, Seats...) and second to our homes cars are the most expensive thing we in England have to invest in.
For the rest of the UK it is not so clear cut. Not only has England borne the brunt of the mass exodus out of Europe into our country but also the EU has been more active in supporting and subsidising projects in the other kingdoms of the UK for which it has more sympathy.
I think England should vote to leave the EU but with that decision we must recognise the need to allow the other Kingdoms of the UK the opportunity to break away by allowing them to have their own referendums on independence. It's only fair (that ambiguous word).
On leaving we could impose import duties on all the Mercs, VWs etc. while saving billions in our membership fees in what is an increasingly one way street- people coming in and revenue going out.
David Cameron knows how inequitable our relationship with the EU is on many levels. I doubt he will succeed in righting them though his electoral success demands that we should support his efforts.
A non-EU England with our huge consumer base would be able to enter into reciprocal trade arrangements with the rest of the world as it is today, especially the Commonwealth, into which I feel it's high time to invite the US to join.
The Scottish supremacists brought this on by showing how over-represented they are in the UK government in proportion to the number of UK citizens that voted for them in comparison with UKIP.
They crossed the Rubicon at the general election and the sooner they leave the better for both countries in the long term. I would say the best solution would be if Scotland Wales and Northern Ireland formed their own nation after rejoining the EU and made their own way in the world. They blame England for everything but like all children realise when they grow up they have to realise that the only person you should blame is yourself.