I couldn't function without coffee in the morning and I do like alcohol. Chocolate too.
I was a long distance runner in my youth and got off on the endorphins. These days I get them from singing.
I used to smoke dope but don't any more. It is highly overrated really.
Did LSD once many, many years ago. It was nice.
Psilocybin (magic mushrooms) was also interesting but didn't really appeal that much.
Diviner's Sage (Salvia Divinorum) I did once. It is very interesting and by far the most powerful thing I have taken. The main rush is short but I think its influence over me lasted indefinitely.
However nothing comes close in overall psychoactive experience to Ayahuasca, which I did once in a remote community in the upper reaches of the Napo river in Ecuador. It was prepared for me by a Quechua Shaman. It was a beautiful experience, powerfully spiritual and very deeply introspective.
Unlike other drugs which seem profound at the time but don't hold up in the light of the day after, the insights given to me by Ayahuasca took many years to fully comprehend.