No one would give you advice on this in this economic climate - and if they do - beware.
However, without knowing what your holdings are, I would say that if you do not need the money at the present time it would be foolish to sell in such a depressed market.
A loss is not a loss until it is crystallized.
This is only general advice - not knowing your circumstances - but things tend to go in circles (even economic circumstances) and one day the market will recover.
The Jews have a tremendous saying - This Too Will Pass.
It applies equally to good times as well as bad and acts as a warning to prepare during good times but to have hope during bad times.