No, it is not to do with air getting in the system. Folks on this site seem obsessed with believing that radiator bleeding is a necessary and routine operation that is required on CH systems.
The most likely issue is that the system is not balanced properly - meaning that very little hot water finds its way into the faulty rad. It happens because there is too much resistance to water flow into that room because the path the water has to take is the longest length of pipework.
The way you may be able to correct this is to try unscrewing the lockshield valve (at the other end to the valve you say is full on) anticlockwise. Try turning it one quarter turn at a time, then see what effect it has. If this won't work (because it is completely unscrewed already) you will have to ask a heating technician to do it for you (because every lockshield in the house will have to be reset-up).