My suggestions
Ashley becomes a Hells Angel
His ex missus goes on the game
Cain has a sex change operation
Charity becomes a priest and goes on to become a bishop
Rachel leaves and becomes an ITN newscaster
Paddy takes over from Paul Hollywood - who takes the role of Roland the Rat Vet
The lesbians split up and each gives birth to quadruplets, Sam being the father
Angel grows up to be a sex pervert, Nicola gets a makeover that goes wrong, the surgeon putting boob silicons in her butt. Jimmy takes on the role of village ijiut rather than numpty.
Jay and his family move to Notlobistan to take over the Manchester Evening News
The hotel becomes a brothel, Victoria as chief madame, Belle as the ho, along with Valerie, who sets herself up as Mrs Pain
The Inn comes under the management of Moira and opens as a milk bar
Andy Sugden becomes a brain surgeon
Rodney becomes a Police Inspector
and Carl re-enters as a risen-again Jesus.