Guardian Prize

[SimonG]

I'm now down to four clues left, assuming I ignore the numerous ones that refer to compilers who I don't believe ever existed... so I would really appreciate help on:
5A Signicant other starting out unsteadily - _ _ _ _ O _ I _
18A Express finally comes to junction out east - no letters!
5D Notes from Taupi as he does needlework outside - _ R O _ _ _ E _ S
6D Complaint made by Imogen and head about pupils - _ _ L _ _ S

Any help gratefully received - thanks!

[pomona]

5a take letters of starting out of significant other and jumble ... to get a setter

[Captain2]

5d Cro-t-chets

[Lie-in King]

5a Chifonie (setter) - anag '(sign)ific(a)n(t) o(t)he(r)' ('starting', out)
18a Screw (setter) '(expres)s' (finally) + 'Crew(e-ast)'
5d Crotchets - 'crochets' (outside) 'T(aupi)'
6d Illness - 'I(mogen) + ness (head)' (about) 'll(earners)'

[SimonG]

Many thanks - I can now rest in peace... so to speak