se 1000

[nixon2]

41a very strict or austere
52a a yellowish red dye obtained from the seeds of a tropical american tree
10d informing telling
22a flouride poisoining caused by the ingestion of too much flouride

[Lie-in King]

41a Spartan
52a Annatto
10d Notifying
22a Fluorosis

It's always nice to post the number of letters & any you have placed, so that people without the puzzle can more readily assist - thanks! :-)

Happy Easter!