To endorse what Pippa says, you'll find that straight people go to gay clubs in Brighton and vice versa; there's much more acceptance of other lifestyles down here.
I'm straight but my favourite club when I was growing up was the Curtain Club (sadly no more) as it played much better music than the identikit discos. I never felt out of place there, nor in any of the other gay clubs I have been to.
I used to go clubbing nearly every night - about 25 years ago - but I'm a bit too old for that sort of thing now, so I have no idea as to where's hot or not.
My night out tonight is Shakespeare in the park ....in Worthing. It's one foot in the grave, I tell you. :-)