Earth your self by touching something like a radiator before touching the card or the inside of the computer.
Watch out for a little clip at the front edge of the slot the card goes into that may be holding the current card in.
it requires more force than most people realise to remove and insert the cards, so don't be afraid to use fairly firm force (not too silly of course!)
it's often better to download the latest drivers from the card manufactures site rather than use the ones on the CD which will be out of date probably.